Peter Parker is unmasked and no longer able to separate his normal life from the high-stakes of being a super-hero. When he asks for help from Doctor Strange the stakes become even more dangerous, forcing him to discover what it truly means to be Spider-Man.
Struggling to find his place in the world while juggling school and family, Brooklyn teenager Miles Morales is unexpectedly bitten by a radioactive spider and develops unfathomable powers just like the one and only Spider-Man. While wrestling with the implications of his new abilities, Miles discovers a super collider created by the madman Wilson "Kingpin" Fisk, causing others from across the Spider-Verse to be inadvertently transported to his dimension.
Doormat Wesley Gibson is an office worker whose life is going nowhere. He meets an attractive woman named Fox and discovers that his recently murdered father - whom Wesley never knew - belonged to the Fraternity, a secret society of assassins which takes its orders from Fate itself. Fox and Sloan, the Fraternity's leader, teach Wesley, through intense training, to tap into dormant powers and hone his innate killing skills. Though he enjoys his newfound abilities, he begins to suspect that there is more to the Fraternity than meets the eye.
With his marriage fraying, Blake persuades his wife Charlotte to take a break from the city and visit his remote childhood home in rural Oregon. As they arrive at the farmhouse in the dead of night, they're attacked by an unseen animal and barricade themselves inside the home as the creature prowls the perimeter. But as the night stretches on, Blake begins to behave strangely, transforming into something unrecognizable.
When 93-year-old Thelma Post gets duped by a phone scammer pretending to be her grandson, she sets out on a treacherous quest across the city to reclaim what was taken from her.